产品分类/PRODUCT CLASSIFICATION
| 规格 | 价格 | 库存 |
|---|---|---|
| 50ul | ￥ 1200 | 8 |
| 100ul | ￥ 1900 | 5 |
| 200ul | ￥ 2900 | 3 |
| 产品编号 | Ys-11354R |
| 英文名称 | Piccolo |
| 中文名称 | 神经细胞突触蛋白PCLO抗体 |
| 别 名 | ACZ; Aczonin; Brain-derived HLMN protein; DKFZp779G1236; KIAA0559; Multidomain presynaptic cytomatrix protein; PCLO; PCLO_HUMAN; Piccolo (presynaptic cytomatrix protein); Piccolo, mouse, homolog of antibody Pico; Presynaptic cytomatrix protein; Protein piccolo. |
| 研究领域 | 细胞生物 神经生物学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, (predicted: Mouse, Rat, Dog, Pig, Cow, ) |
| 产品应用 | ELISA=1:5000-10000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理论分子量 | 557kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Piccolo: 4951-5056/5056 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 缓 冲 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 产品介绍 | Piccolo is 1 component of the presynaptic cytomatrix. Bassoon is a large protein which is also found in the presynaptic compartments of rat brain synapses. Bassoon, along with Piccolo, is part of the ensemble of presynaptic proteins that are involved in orchestrating events at the nerve terminal. Bassoon is found in axon terminals of hippocampal neurons where it is highly concentrated in the vicinity of the active zone. Piccolo has a similar distribution and colocalizes with Bassoon in cultured hippocampal cells. Piccolo zinc fingers interact with the dual prenylated rab3A and VAMP2/ Synaptobrevin II receptor PRA. Bassoon may be involved in cytomatrix organization at the site of neurotransmitter release. The gene which encodes bassoon maps to human chromosome 3p21.31. The gene which encodes piccolo maps to human chromosome 7q21.11. Function: May act as a scaffolding protein involved in the organization of synaptic active zones and in synaptic vesicle trafficking. Subunit: Interacts with RABAC1/PRA1, RIMS2 and profilin (By similarity). Subcellular Location: Cell junction, synapse. Note=Concentrated at the presynaptic side of synaptic junctions. Similarity: Contains 2 C2 domains. Contains 1 PDZ (DHR) domain. |
