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增生性息肉蛋白1抗体
产品名称:
增生性息肉蛋白1抗体
英文名称:
TMEFF2
产品类别:
抗体
产品编号:
Ys-3849R
产品应用:
WB ELISA IHC-P IHC-F IF
性状:
Liquid
纯化方法:
affinity purified by Protein A
保质期:
12个月
保存条件:
Shipped at 4℃. Store at -20 °C for one year. Avoid
[价格]
规格 价格 库存
50ul ¥ 1200 5
100ul ¥ 1900 3
200ul ¥ 2900 3

产品详情

 

产品编号 Ys-3849R
英文名称 TMEFF2
中文名称 增生性息肉蛋白1抗体
别    名 Tomoregulin-2; HPP 1; HPP1; Hyperplastic polyposis protein 1; TEFF 2; TEFF2; TENB 2; TENB2; Tomoregulin; TPEF; TR; Transmembrane protein containing epidermal growth factor and follistatin domains ; Transmembrane protein TENB2; Transmembrane protein with EGF like and two follistatin like domains 2; TEFF2_HUMAN.  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Rat,  (predicted: Mouse, Chicken, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig, )
产品应用 WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 37kDa
细胞定位 分泌型蛋白 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TMEFF2: 301-374/374 
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 TMEFF2 is a growth factor implicated in the progression of prostate cancer. It is highly expressed in the brain and may act as a survival factor for mesencephalic and hippocampal neurons.

Function:
May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation.

Subcellular Location:
Isoform 1: Membrane; Single-pass type I membrane protein (Potential).
Isoform 2: Membrane; Single-pass type I membrane protein (Potential).
Isoform 3: Secreted.

Tissue Specificity:
Highly expressed in adult and fetal brain, spinal cord and prostate. Expressed in all brain regions except the pituitary gland, with highest levels in amygdala and corpus callosum. Expressed in the pericryptal myofibroblasts and other stromal cells of normal colonic mucosa. Expressed in prostate carcinoma. Down-regulated in colorectal cancer. Present in Alzheimer disease plaques (at protein level). Isoform 3 is expressed weakly in testis and at high levels in normal and cancerous prostate.

Post-translational modifications:
N-glycosylated. Contains chondroitin sulfate glycosaminoglycans.
A soluble form (TMEFF2-ECD) is produced by proteolytic shedding. This shedding can be induced by phorbol ester or proinflammatory cytokines such as TNFalpha, and is mediated by ADAM17.

Similarity:
Belongs to the tomoregulin family.
Contains 1 EGF-like domain.

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