产品编号 Ys-2420R
英文名称 NCR2
中文名称 细胞毒性受体NK-p44抗体
别 名 Natural killer cell p44-related protein; CD336; CD336 antigen; LY95; Lymphocyte antigen 95 homolog; Lymphocyte antigen 95 (activating NK receptor; NK p44); Natural cytotoxicity triggering receptor 2; Natural killer cell p44-related protein; NK cell activating receptor; NK p44; NKp44; NCTR2_HUMAN; dJ149M18.1; Lymphocyte antigen 95 (activating NK receptor; NK p44).
研究领域 细胞生物 免疫学 信号转导 细胞膜受体 自然杀伤细胞 t-淋巴细胞
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human,
产品应用 ELISA=1:5000-10000 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 28kDa
细胞定位 细胞膜
性 状 Liquid
浓 度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CD336: 201-276/276
亚 型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 NCR2 (NKp44) is a member of the natural cytotoxicity receptor (NCR) family that is expressed on activated human NK cells. NCR2 displays a single extracellular Ig-like V domain and a transmembrane portion containing the charged residue (Lysine), likely involved in the association with KARAP/DAP12 molecules. Gene coding for NCR2 maps on human chromosome 6p21.1
Function:
Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.
Subunit:
Interacts with TYROBP/DAP12.
Subcellular Location:
Cell membrane; Single-pass type I membrane protein (Potential).
Tissue Specificity:
Selectively expressed by activated NK cells and by in vitro cultured (i.e. activated) TCRg/d lymphoid cells.
Similarity:
Belongs to the natural cytotoxicity receptor (NCR) family.
Contain
