英文名称 Osteocrin
中文名称 肌肉素抗体
别 名 Musclin; OSTN; OSTN_HUMAN.
研究领域 细胞生物 干细胞
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
产品应用 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 3.2kDa
细胞定位 分泌型蛋白
性 状 Liquid
浓 度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Osteocrin:83-133/133
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed PubMed
产品介绍 Musclin, also designated osteocrin (Ostn), shows no homology with any known genes, except that it contains two conserved sequence motifs homologous to the natriuretic peptide family. Musclin is highly expressed in cells of osteoblast lineage and in skeletal muscle tissue, where it is tightly regulated by nutritional changes. It is secreted as either a full-length precursor protein or a processed form. A novel skeletal muscle-derived secretory factor, Musclin may play a role in bone formation and be linked to glucose metabolism. Studies indicate that insulin increases Musclin expression, whereas epinephrine, isoproterenol and forskolin reduce its expression. Musclin is expressed in osteoblasts and young osteocytes. In mouse tissues, expression is bone-specific, although minimal Musclin expression is also observed in muscle, kidney, testis and heart tissues.
Function:
Appears to modulate osteoblastic differentiation. Could also function as an autocrine and paracrine factor linked to glucose metabolism in skeletal muscle.
Subcellular Location:
Secreted.
Tissue Specificity:
Expressed in bone.
SWISS:
P61366
Gene ID:
344901
Database links:
Entrez Gene: 344901 HumanEntrez Gene: 239790 MouseEntrez Gene: 360730 RatOmim: 610280 HumanSwissProt: P61366 HumanSwissProt: P61364 Mouse
