研究领域 ：神经生物学
抗体来源 ：Rabbit
克隆类型 ：Polyclonal
交叉反应 ：Mouse, (predicted: Human, Rat, )
产品应用： WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 ：86kDa
细胞定位： 分泌型蛋白
性 状： Liquid
浓 度 ：1mg/ml
免 疫 原： KLH conjugated synthetic peptide derived from mouse Sema5A:22-120/772
亚 型 ：IgG
纯化方法 ：affinity purified by Protein A
储 存 液 ：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 ：Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed PubMed
产品介绍 ：This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease.
Function:
Plays a role in growth cones guidance. May function to pattern sensory projections by selectively repelling axons that normally terminate dorsally. Involved in the development of the olfactory system and in neuronal control of puberty.
Subunit:
Interacts with PXND1.
Subcellular Location:
Secreted.
Tissue Specificity:
Expressed at relatively high levels in brain and muscle, moderate levels in lung, bursa, and heart and virtually absent in liver. Collapsin-1, -2, -3, and -5 bind to overlapping but distinct axon tracts.
Similarity:
Belongs to the semaphorin family.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 PSI domain.
Contains 1 Sema domain.
SWISS:
O08665
Gene ID:
20346
Database links:Entrez Gene: 10371 HumanEntrez Gene: 20346 MouseEn
