英文名称:Semaphorin 5A
中文名称：跨膜蛋白SEMA5A抗体
研究领域：细胞生物 神经生物学 细胞膜蛋白
抗体来源：Rabbit
克隆类型：Polyclonal
交叉反应：Human, (predicted: Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep, )
产品应用：WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量：118kDa
细胞定位：细胞膜
性 状：Liquid
浓 度：1mg/ml
免 疫 原：KLH conjugated synthetic peptide derived from human Semaphorin 5A:671-770/1074
亚 型：IgG
纯化方法：affinity purified by Protein A
储 存 液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件：Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍：This gene belongs to the semaphorin gene family that encodes membrane proteins containing a semaphorin domain and several thrombospondin type-1 repeats. Members of this family are involved in axonal guidance during neural development. This gene has been implicated as an autism susceptibility gene.
Function:
Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis.
Subunit:
Binds PLXNB3.
Subcellular Location:
Membrane; single-pass type I membrane protein
Similarity:
Belongs to the semaphorin family.
Contains 1 PSI domain.
Contains 1 Sema domain.
Contains 7 TSP type-1 domains.
SWISS:
Q13591
Gene ID:
9037
Database links:
Entrez Gene: 9037 Human
Entrez Gene: 20356 Mouse
Omim: 609297 Human
SwissProt: Q13591 Human
SwissProt: Q62217 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
| 产品图片 | Sample:
A549(Human) Cell Lysate at 30 ug
Primary: Anti-Semaphorin 5A (20430R) at 1/500 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 118 kD
Observed band size: 118 kD |
