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首页 > 上海细胞库 > 人源细胞系
I 2.1（人急性淋巴细胞白血病细胞）
产品名称：
I 2.1（人急性淋巴细胞白血病细胞）
产品编号：
RE59742
产品类别：
人源细胞系
生长特性：
贴壁生长
细胞形态：
lymphoblast
冻存条件：
90%FBS+10%DMSO
  • 冻存条件：90%FBS+10%DMSO
    • [价格]
    规格 价格 库存
    T25 ￥ 2600 200

    产品详情

    Synonyms: I 2.1(人急性淋巴细胞白血病细胞)
    Background: The I 2.1 cell line is a FADD mutant of the wild-type Jurkat cell line A3 (see ATCC -CRL-2570). Wild-type A3 cells were made neomycin resistant and treated with three cycles of exposure to the frameshifting mutagen ICR-191 to isolate clones harboring recessive mutations that were resistant to killing by Fas antibody. Ref
    ICR-191 treated clones were serially diluted in 96-well plates in the presence of Fas Antibody for 3 to 5 weeks. Ref Two of these ICR-191 treated clones have been deposited at the ATCC . They are I 9.2 (ATCC CRL-2571), a clone with a mutation in the cysteine protease caspase-8/FLICE and I 2.1 (ATCC CRL-2572), a clone with a mutation in the adaptor FADD. 
    Species: Homo sapiens, human
    Disease: acute T cell leukemia
    Gender: male
    Morphology: lymphoblast
    Growth Mode: suspension
    DNA Profile: Amelogenin: X,Y
    CSF1PO: 11,12
    D13S317: 8,11
    D16S539: 11
    D5S818: 9
    D7S820: 8,10
    THO1: 6,9.3
    TPOX: 8,10
    vWA: 17,18
    Cell Line Authentication Service
    Culture Medium: RPMI-1640+15%FBS
    We strongly suggest to purchase the complete medium
    Cryopreservation medium: 90%FBS+10%DMSO
    Comments: Unlike the parental line A3 that does express FADD, the I 2.1 cell line does not express FADD protein by immunoblot analysis and is completely resistant to Fas-induced death. Complementation of the I 2.1 cell lines with wild-type FADD restores Fas-mediated apoptosis. Fas activation of caspase-2, caspase-3, caspase-7, and caspase-8 is completely defective in the FADD mutant cell line I 2.1. Ref
    This cell line can be used to study the role of FADD in apoptotic signaling pathways in the absence of overxpression.
     

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