英文名称

AHR

中文名称

芳香烃受体抗体

别    名

Ah receptor; Aromatic hydrocarbon receptor; Aryl hydrocarbon receptor; Aryl hydrocarbon receptor precursor; BHLHE76; Class E basic helix loop helix protein 76; HGNC:348; AHR_HUMAN.   

研究领域

肿瘤  免疫学  信号转导  转录调节因子  

抗体来源

Rabbit

克隆类型

Polyclonal

交叉反应

Human, Rat,  (predicted: Mouse, )

产品应用

ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=2ug/Test IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分 子 量

93kDa

细胞定位

细胞核 细胞浆 

性    状

Liquid

浓    度

1mg/ml

免 疫 原

KLH conjugated synthetic peptide derived from human Aryl Hydrocarbon Receptor:10-120/948 

亚    型

IgG

纯化方法

affinity purified by Protein A

储 存 液

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMed

PubMed

产品介绍

This gene encodes a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Its ligands included a variety of aromatic hydrocarbons.

Function:
Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues.

Subcellular Location:
Cytoplasm. Nucleus. Initially cytoplasmic; upon binding with ligand and interaction with a HSP90, it translocates to the nucleus.

Tissue Specificity:
Expressed in all tissues tested including blood, brain, heart, kidney, liver, lung, pancreas and skeletal muscle.

Similarity:
Contains 1 basic helix-loop-helix (bHLH) domain.
Contains 1 PAC (PAS-associated C-terminal) domain.
Contains 2 PAS (PER-ARNT-SIM) domains.

SWISS:
P35869

Gene ID:
196

Database links:

Entrez Gene: 196 Human

Entrez Gene: 11622 Mouse

Entrez Gene: 25690 Rat

Omim: 600253 Human

SwissProt: P35869 Human

SwissProt: P30561 Mouse

SwissProt: P41738 Rat

Unigene: 171189 Human

Unigene: 341377 Mouse

Unigene: 91370 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

转录调节因子（Transcriptin Regulators）
芳香烃受体（AHR）是一种配体激活转录因子,可介导多环芳烃类化合物的毒性（包括致癌性）反应,还参与一些重要的生物学过程,如信号转导、细胞分化、细胞凋亡等。人体的肺、肝、肾、胎盘、腭扁桃体、B淋巴细胞等各种组织和细胞中都存在AHR。AHR对生长发育和生理功能等具有调控作用,在一些癌症（乳腺癌和卵巢癌等）发生发展中起促进作用。