产品分类/PRODUCT CLASSIFICATION
| 中文名称 | 白细胞介素28抗体 |
| 别 名 | Interleukin 28/Interferon lambda-2; Interleukin 28A; IL28A; IFNL2; IL-28A; EG330496; Ifnl2; IFNL2_HUMAN. |
| 研究领域 | 细胞生物 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | (predicted: Human, ) |
| 产品应用 | WB=1:200-2000 ELISA=1:5000-20000 IHC-P=1:100-500 IHC-F=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 20kDa |
| 细胞定位 | 分泌型蛋白 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human IL-28:131-180/196 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 产品介绍 | This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28B (IL28B), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008] Function: Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Subcellular Location: Secreted. Similarity: Belongs to the lambda interferon family. SWISS: Q8IZJ0 Gene ID: 282616 Database links: Entrez Gene: 282616 Human Entrez Gene: 330496 Mouse Omim: 607401 Human SwissProt: Q8IZJ0 Human SwissProt: Q4VK74 Mouse Unigene: 567792 Human Unigene: 454510 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品图片 |  Sample:MCF-7(human) cell Lysate at 30 ug Primary: Anti-IL-28 (bs-23760R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 20kD Observed band size: 20 kD  Immunohistochemical analysis of paraffin-embedded human-spleen, antibody was diluted at 1:100 Immunohistochemical analysis of paraffin-embedded human-spleen, antibody was diluted at 1:100 Immunohistochemical analysis of paraffin-embedded human-tonsil, antibody was diluted at 1:100 Immunohistochemical analysis of paraffin-embedded human-tonsil, antibody was diluted at 1:100 Immunohistochemical analysis of paraffin-embedded human-tonsil, antibody was diluted at 1:100 |
