产品分类/PRODUCT CLASSIFICATION
| 中文名称 | 跨膜蛋白Smoothened抗体 |
| 别 名 | Gx; Gx protein; SMO; SMOH; Smoothened homolog (Drosophila); Smoothened homolog; Smoothened homolog precursor (SMO) (Gx protein); SMO_HUMAN. |
| 研究领域 | 肿瘤 免疫学 信号转导 细胞膜受体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Mouse, (predicted: Human, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, ) |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 84kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Smoothened:551-650/787 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 产品介绍 | The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex. [provided by RefSeq, Jul 2010] Function: G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia. Subunit: Interacts with ARRB2. Interacts with KIF7. Subcellular Location: Membrane. Similarity: Belongs to the G-protein coupled receptor Fz/Smo family. Contains 1 FZ (frizzled) domain. SWISS: Q99835 Gene ID: 6608 Database links: Entrez Gene: 395949 Chicken Entrez Gene: 100033990 Horse Entrez Gene: 6608 Human Entrez Gene: 319757 Mouse Entrez Gene: 25273 Rat Entrez Gene: 30225 Zebrafish Omim: 601500 Human SwissProt: O42224 Chicken SwissProt: Q99835 Human SwissProt: P56726 Mouse SwissProt: P97698 Rat Unigene: 437846 Human Unigene: 29279 Mouse Unigene: 44429 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品图片 |  Sample:Kidney (Mouse) Lysate at 40 ug Primary: Anti-Smoothened (bs-2801R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 84 kD Observed band size: 84 kD |
