作者列表：Yantuanjin Ma, Yuhang Zhang, Qiuyue He, Tong Xu, Wei Huang, Xingli Deng, Yuan Qian

影响因子：4.6

期刊：PHYSIOLOGICAL GENOMICS

发表时间：2023-6-23

DOI:10.1152/physiolgenomics.00004.2023

文献主题：

Abstract

Abstract

Preeclampsia is a pregnancy-specific disease, which has become an essential cause of perinatal ａnd neonatal death. Gut microflora becomes the regulator of host immunity through the metabolic pathway. Epidemiological studies provide convincing evidence that vitamin D supplementation can prevent the onset of preeclampsia. However, research on the microbial mechanisms ａnd effective treatment strategies for placental inflammation induced by lipopolysaccharide is lacking. In this study, pregnant rats were induced by LPS to establish a rat model of preeclampsia. Sixteen-sequence analysis was used to determine the composition of microflora in feces. In addition, the protective effect of vitamin D supplementation on LPS-preeclampsia rats was evaluated. The results showed that the blood pressure ａnd creatinine of pregnant rats in the LPS group were significantly higher than those in the control group. In addition, LPS disturbed the intestinal microbial community ａnd reduced microbial diversity. Vitamin D supplementation improves the symptoms of preeclampsia, increases the abundance of intestinal beneficial flora, normalizes the level of inflammatory factors LPS-induced by inhibiting the TLR4/MYD88/NF-κB pathway, ａnd effectively resists the disturbance of uterine spiral artery remodeling induced by LPS. This study established that vitamin D-mediated microbial mechanisms ａnd their inhibition are potential therapeutic targets for the treatment of preeclampsia.