文章标题：Exogenous Na2SiO3 Mitigates the Adverse Effects of Drought Stress on Cucumber Seed Germination by Regulating the AsA-GSH Cycle

作者列表：Kexin Chen, Zitong Liu, Xin Meng, Shuyan Jiang, Li Jin, Shuya Wang, Shuchao Huang, Jian Lyu, Ning Jin, Jihua Yu

发表时间：2026-2-18

期刊：Horticulturae

影响因子：3

DOI:10.3390/horticulturae12020243

主要研究成果：Abstract

Cervical cancer （CC） remains a significant global health burden despite advances in prevention ａnd screening. Emerging evidence highlights the critical role of long non-coding RNAs （lncRNAs） ａnd RNA modifications in tumorigenesis. Here, we identified LINC01094 as a highly expressed lncRNA in CC through TCGA analysis ａnd clinical specimens. Functional studies, including CCK-8 method, flow cytometry, Transwell ａnd Western blot assays, demonstrated that LINC01094 knockdown suppressed cell proliferation, migration, ａnd epithelial-mesenchymal transition while promoting apoptosis in CC cells （Caski ａnd SiHa）. Mechanistically, NSUN2-mediated 5-methylcytosine methylation stabilized LINC01094, enhancing its expression in CC. Furthermore, LINC01094 facilitated ZNF582-dependent transcriptional activation of SIRT1, promoted the deacetylation ａnd degradation of p53. Rescue experiments confirmed that ectopic expression of either LINC01094 or SIRT1 reversed the tumor-suppressive effects of NSUN2 or LINC01094 knockdown, respectively. Collectively, NSUN2-mediated stabilization of LINC01094 upregulated SIRT1 expression, thereby suppressing the p53 pathway ａnd accelerating CC progression. These findings uncover a novel NSUN2/LINC01094/SIRT1 axis as an epigenetic-transcriptional driver of CC, offering potential therapeutic targets.